Synthetic Route of 2434-53-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.
General procedure: A solution of 6-aminouracils 1 (1.0mmol), alpha-azidochalcones 2 (1.0mmol), and NEt3 (0.5mmol) in DMF (4mL) was heated at 50C for 30min. After completion of the reaction which was monitored by TLC, the mixture was cooled down to room temperature. Then, water (10mL) was added to the mixture and extracted three times with EtOAc (3¡Á15mL). The combined organic extracts were washed with brine, dried over Na2SO4 and then concentrated. The precipitate was filtered and washed with Et2O to afford pure product 3.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2434-53-9, 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Article; Adib, Mehdi; Peytam, Fariba; Rahmanian-Jazi, Mahmoud; Mahernia, Shabnam; Bijanzadeh, Hamid Reza; Jahani, Mehdi; Mohammadi-Khanaposhtani, Maryam; Imanparast, Somaye; Faramarzi, Mohammad Ali; Mahdavi, Mohammad; Larijani, Bagher; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 353 – 363;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia