As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 24391-41-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, molecular formula is C7H3ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyrimidines
To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (100 mg, 0.56 mmol, 1.00 equiv) in t-BuOH (15 mL) was added trans -N,N-dimethylcyclohexane-l,4-diamine (360 mg, 1.67 mmol, 3.0 equiv) and Et3N (3 ml). The resulting solution was stirred overnight at 100C in an oil bath. The resulting mixture was concentrated under vacuum and the residue was purified by Flash-Prep-HPLC with the following conditions: Column, SunFire Prep CI 8, 19* 150mm 5um; mobile phase, water with 0.05% NH4HC03 and CH3CN (8.0% CH3CN up to 65.0% in 14 min); Detector, 254/220nm. This resulted in 20.0 mg of 4-((-4- (dimethylamino)cyclohexyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile as white solid. LCMS: (ES, m/z): 285[M+H]+ 1H NMR-(300 MHz, CD3OD, ppm): delta 8.22 (1H, d), 7.81 (1H, s), 3.95-4.05 (1H, m), 2.30-2.40 (7H, m), 2.23-2.29 (2H, m), 1.95-2.05 (2H, m),1.30-1.50 (4H, m).
With the rapid development of chemical substances, we look forward to future research findings about 24391-41-1.
Reference:
Patent; NIMBUS IRIS, INC.; HARRIMAN, Geraldine C.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; WESSEL, Matthew David; GREENWOOD, Jeremy Robert; WO2014/11911; (2014); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia