Adding a certain compound to certain chemical reactions, such as: 25940-35-6, Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, blongs to pyrimidines compound. Safety of Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
To the mixture of pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (42 mg, 0.26 mmol) and diisopropylethylamine (0.09 mL, 0.52 mmol) in DMF (2 mL) was added 2-(7-aza-1H- benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (131 mg, 0.34 mmol) then the mixture was stirred at 25 oC for 15 min. To the mixture was added a solution of 2-[4-(5- amino-2,2-dimethyl-3H-benzofuran-6-yl)piperazin-1-yl]ethanol (50 mg, 0.17 mmol) in DMF (2 mL) and the resulting mixture was stirred at 25 oC for 16h. The mixture was purified by preparative HPLC(Xbridge 21.2*250 mm c18, 10um, A: acetonitrile 10-70%; B:10 mM ammonium bicarbonate in water) to afford N-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2,2- dimethyl-3H-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (45 mg, 60%) as a yellow solid.1H NMR (400 MHz,DMSO-d6) delta 10.42(s, 1H), 9.37(dd, J = 1.6 , 7.2Hz, 1H), 8.92 (dd, J = 1.6, 4.4Hz, 1H), 8.68(s, 1H), 8.31(s, 1H), 7.36(dd, J = 4.4,7.2Hz, 1H), 6.69(s, 1H), 4.45(t, J =5.2Hz, 1H), 3.54(q, J = 5.6 Hz, 2H), 3.00(s, 2H), 2.84-2.78(m, 4H), 2.74-2.61 (m, 4H), 2.50(t, J = 5.6 Hz ,2H), 1.41(s, 6H). MS (ESI): m/z = 437.3 [M+1]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,25940-35-6, Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BRYAN, Marian, C.; GOBBI, Alberto; KIEFER, James, Richard, Jr.; KOLESNIKOV, Aleksandr; OLIVERO, Alan, G.; DROBNICK, Joy; LIANG, Jun; RAJAPAKSA, Naomi; (846 pag.)WO2017/108723; (2017); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia