Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5HCl3N2O
General procedure: 2-Aminothiazole (1 g, 0.01 mol), DMAP (80 mg) and TEA (4 ml) were dissolved in THF (30 ml), and compound 7 (4.2 g, 0.02 mol) in THF (30 ml) was added dropwise with stirring. The mixture was stirred until 2-aminothiazole was disappeared. The mixture was filtered, and the solvent was removed in vacuo. Crude products were purified by flash chromatography on silica gel and yellow solid (compound 8, 550 mg) was obtained, yield 20%.
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Reference:
Article; Zhang, Leilei; Hu, Shengquan; Lei, Lei; Zhang, Yuliang; Zhang, Lijing; Song, Hongrui; Shen, Zhufang; Feng, Zhiqiang; Letters in drug design and discovery; vol. 14; 3; (2017); p. 252 – 261;,
Pyrimidine | C4H4N2 – PubChem,
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