New learning discoveries about (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate

Reference of 764659-72-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 764659-72-5.

Reference of 764659-72-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 764659-72-5, Name is (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate, SMILES is O=C([C@@H]1O[C@H](N2C=C(F)C(N)=NC2=O)CS1)O[C@H]3[C@H](C(C)C)CC[C@@H](C)C3, belongs to pyrimidines compound. In a article, author is Li, Dong, introduce new discover of the category.

Novel insights into the roles of RNA N-6-methyladenosine modification in regulating gene expression during environmental exposures

N-6-methyladenosine (m(6)A) is one of the most common RNA modifications in eukaryotes involved in the regulation of post-transcriptional gene expression, as well as the occurrence and development of diseases related to environmental exposures. Adverse factors produced by environmental exposures, such as reactive oxygen species, inflammation, and cyclobutane pyrimidine dimers, mediate m(6)A modification, thereby regulating downstream gene and protein expression, and signaling pathways, such as FTO/m(6)A RNA/p53 axis, PI3K/AKT/mTOR pathway, and PARP/METTL3/m(6)A RNA/Pol kappa pathway. Moreover, an imbalance in m(6)A methylation levels directly mediates disease pathogenesis. To date, some studies have detailed the mechanisms underlying environmental exposure-mediated global changes in RNA m(6)A methylation. Based on our current understanding, we aimed to elaborate on the molecular mechanisms through which RNA m(6)A methylation regulates gene expression under environmental exposures. In this review, we outline the biogenesis and functions of RNA m(6)A modification. Furthermore, we focus on the effects of environmental exposures on m(6)A levels and highlight the relationships between environmental exposures (doses and time) and m(6)A levels. Although the molecular mechanisms regulating gene expression remains to be elucidated, m(6)A has potential applications as a disease biomarker. (C) 2020 Elsevier Ltd. All rights reserved.

Reference of 764659-72-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 764659-72-5.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia