In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3073-77-6, name is 2-Amino-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Amino-5-nitropyrimidine
Example 47. 3-(5-Nitropyrimidin-2-vIamino)-N-(2-hvdroxyethyl)-iV- isopropvlbenzamide (33); [0187] A mixture of 5-nitro-pyrimidin-2-ylamine (141 mg, 1.0 mmol), bromide intermediate 32 described in Example 46 (301 mg, 1.1 mmol), Cs2CO3 (1.3 g, 4.0 mmol), Xantphos (117 mg, 0.2 mmol), and Pd2(dba)3 (92 mg, 0.1 mmol) in dioxane (20 mL) was purged with argon for 5 min, and the suspension was heated to reflux for 16 h. under argon. Dioxane was removed in vacuo, and the crude mixture was adsorbed onto silica gel and purified using an Isco flash chromatography system (0% to 30% Methanol with 1% NH4OH in DCM) to afford a tan solid (142 mg, 41%).1H NMR (DMSO-d6) delta 1.11 (bs, 6H), 3.33-3.36 (m, 2H), 3.56 (bs, 2H), 3.87 (bs, IH), 4.76 (bs, IH), 7.08 (d, J= 7.6 Hz, IH), 7.43 (t, J= 7.9 Hz, IH), 7.78 (bs, IH), 7.79 (dd, J = 8.0, 1.5 Hz, IH), 9.25 (s, 2H), 10.94 (s, IH). MS (ES+): m/z = 346 (MH-H)+. LC retention time: 2.21 min.
The synthetic route of 3073-77-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TARGEGEN, INC.; WO2006/101977; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia