In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3177-24-0, name is 2,4-Dichloropyrimidine-5-carbonitrile, the common compound, a new synthetic route is introduced below. Safety of 2,4-Dichloropyrimidine-5-carbonitrile
Example 20. Synthesis of 2-({[3′-(aminomethyl)-2-methyIbiphenyl-3- yIJmethyl}amino)-4-(4,5,7,8-tetrahydroimidazol4,5-dlazepn-6(lH)-yl)pyrmicline-5- carbonitrile; To a solution of (3′-aminomethyl-2′-methyl-biphenyl-3-ylmethyl)-carbamic acid tert-butyl ester (281 mg, 0.86 mmol) and diisopropylethylamine (0.165 mL, 0.95 mmol) in dichloromethane (5.0 mL) was added 2,4-dichloro-pyritnidine-5-carbonitrile (150 mg, 0.86 mmol). The ixn mixture was stirred at room temperature for 70 h, then adsorbed directly onto silica gel and purified by silica gel chromatography eluting with 20-45percent ethyl acetate in hcxancs to afford 254 mg of a colorless oil, identified as a 1:1 mixture of the desired product and the regioisomeric 4-addition product. This mixture was further purified by reverse phase semi-prep HPLC using 60percent acetonitrile/water (0.1percent TFA) as eluent to give 149 mg of {3′-[(4-chloro-5-cyano-pyrimidin-2-ylamino)-methyl]-2′-methyl-biphenyl-3- yhnethyl}-carbamic acid tert-butyl ester as an off-white solid, m/z 486.0 (M + Na)+.To a solution of l,4,5,6,7,8-hexahydro-imidazo[4,5-
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia