New learning discoveries about 4-Amino-5-bromopyrimidin-2(1H)-one

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-25-7, 4-Amino-5-bromopyrimidin-2(1H)-one, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 2240-25-7, 4-Amino-5-bromopyrimidin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Amino-5-bromopyrimidin-2(1H)-one, blongs to pyrimidines compound. Safety of 4-Amino-5-bromopyrimidin-2(1H)-one

EXAMPLE 694-amino-5-(2-(((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)ethylamino)pyrimidin-2(1H)-one 40A solid mixture of 34 (100 mg, 0.306 mmol) and 5-bromocytosine (58 mg, 0.305 mmol) was heated at 150¡ã C. for 4 hours. After the reaction had cooled to room temperature, the product was purified by preparative HPLC to give the title compound 40 as the formate salt in 8.4percent yield (11 mg). 1H NMR (DMSO-d6/D2O) delta (ppm): 8.31 (s, 1H), 8.15 (s, 1H), 8.11 (s, 1H), 6.62 (s, 1H), 5.85 (d, 1H, J=5.6 Hz), 4.70 (dd, 1H, J=5.2, 5.6 Hz), 4.13 (m, 1H), 4.00 (m, 1H), 2.90 (m, 4H), 2.65 (m, 2H). MS calc 435.46; found 436 (MH)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-25-7, 4-Amino-5-bromopyrimidin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; METHYLGENE INC.; US2008/132525; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia