Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5399-92-8, name is 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H3ClN4
Compound 2 (1.88 g, 0.012 mol)was dissolved in EtOAc (50 mL) and heated to 50 C. After 10 min pyridinium 4-toluenesulfonate(PPTs) (50 mg) were added, followed by the addition of 3,4-dihydro-2H-pyran. The resulting reactionmixture was at stirred 50 C. After the reaction was complete according to the TLC detection, themixture was cooled to room temperature, washed with water (60 mL x 1), and a saturated solution ofNaCl (50 mL x 2), and dried over MgSO4. The ethyl acetate was removed and petroleum ether (60 mL x 2) was added. The mixture was heated and filtered through cotton. Removal of petroleum ether invacuo gives compound 3 as light yellow colored solid. Yield: 76.5%. 1H-NMR (400 MHz, DMSO-d6) delta 8.92 (s, 1H), 8.55 (s, 1H), 6.02 (dd, J = 10.4, 2.4 Hz, 1H), 3.97 (d, J = 12.0 Hz, 1H), 3.76-3.70 (m, 1H),2.49-2.42 (m, 1H), 2.07-2.08 (m, 1H), 1.98-1.94 (m, 1H), 1.85-1.73 (m, 1H), 1.64-1.58 (m, 2H). ESI-MSm/z: 239.06 [M + H]+.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5399-92-8, 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine.
Reference:
Article; Fu, Yu; Wang, Yuanyuan; Wan, Shanhe; Li, Zhonghuang; Wang, Guangfa; Zhang, Jiajie; Wu, Xiaoyun; Molecules; vol. 22; 4; (2017);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia