Synthetic Route of 52854-14-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine, molecular formula is C5H4ClN3O3, molecular weight is 189.56, as common compound, the synthetic route is as follows.
General procedure: 4-chloro-6-methoxy-5-nitro-pyrimidine (Preparation R1a; 1.0 eq.), the appropriate phenol (1.2 eq.), and potassium carbonate (1.2 eq.) were dissolved in acetonitrile. It was stirred at 80 C till completion, then water was added to the reaction mixture. MeCN was evaporated. The residue extracted with DCM. The combined organic phase was dried over MgS04 and evaporated under reduced pressure to give R2a-R2ce.
Statistics shows that 52854-14-5 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-6-methoxy-5-nitropyrimidine.
Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; WEBER, Csaba; KOTSCHY, Andras; VASAS, Attila; KISS, Arpad; MOLNAR, Balazs; MACIAS, Alba; FIUMANA, Andrea; DAVIES, Nicholas; MURRAY, James Brooke; SELLIER, Emilie; DEMARLES, Didier; IVANSCHITZ, Lisa; GENESTE, Olivier; (233 pag.)WO2020/8013; (2020); A1;,
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