New learning discoveries about 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,30129-53-4, 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30129-53-4, name is 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H5ClN4, molecular weight is 168.58, as common compound, the synthetic route is as follows.SDS of cas: 30129-53-4

General procedure: To a solution of 7a (50.0 mg, 0.32 mmol) and aminomethyl-benzoic acids 8a (40.6 mg, 0.27 mmol) in triethylamine (66.8 mkL,0.48 mmol), anhydrous DMF (1.5 mL) was added and the reaction mixture was stirred at 80 C for 4 h. The reaction mixture was diluted with ethyl acetate (8 mL) and was washed with water (3×4 mL). The ethyl acetate layer was then dried with anhydrous Na2SO4, and concentrated to give a residue that was subjected to purification through the column chromatography on silica gel with DCM and MeOH (10:1) as eluent to afford the titled compounds 1a (31.1 mg, 43%) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,30129-53-4, 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Qian, Shan; He, Tao; Wang, Wei; He, Yanying; Zhang, Man; Yang, Lingling; Li, Guobo; Wang, Zhouyu; Bioorganic and Medicinal Chemistry; vol. 24; 23; (2016); p. 6194 – 6205;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia