With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30129-53-4, name is 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H5ClN4, molecular weight is 168.58, as common compound, the synthetic route is as follows.SDS of cas: 30129-53-4
General procedure: To a solution of 7a (50.0 mg, 0.32 mmol) and aminomethyl-benzoic acids 8a (40.6 mg, 0.27 mmol) in triethylamine (66.8 mkL,0.48 mmol), anhydrous DMF (1.5 mL) was added and the reaction mixture was stirred at 80 C for 4 h. The reaction mixture was diluted with ethyl acetate (8 mL) and was washed with water (3×4 mL). The ethyl acetate layer was then dried with anhydrous Na2SO4, and concentrated to give a residue that was subjected to purification through the column chromatography on silica gel with DCM and MeOH (10:1) as eluent to afford the titled compounds 1a (31.1 mg, 43%) as a yellow solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,30129-53-4, 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Qian, Shan; He, Tao; Wang, Wei; He, Yanying; Zhang, Man; Yang, Lingling; Li, Guobo; Wang, Zhouyu; Bioorganic and Medicinal Chemistry; vol. 24; 23; (2016); p. 6194 – 6205;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia