Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42754-96-1, name is 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine. A new synthetic method of this compound is introduced below., Product Details of 42754-96-1
A mixture of Compound IA (94.5 mg, 0.5 mmol) and sulfanilamide Compound IB (161.8 mg, 0.6 mmol) in dioxane (5 mL) was refluxed overnight; and was cooled to room temperature. The yellow precipitate was collected by filtration and was separated by HPLC to give Compound 1 as a pale yellow solid (70 mg, 41% based on TFA salt). 1H NMR ((CD3)2CO) delta 10.10 (s, IH), 9.70 (s, IH), 8.22 (s, IH), 8.20 (d, 2H), 8.00 (d, 2H), 7.80 (d, 2H), ), 7.75 (d, 2H), 7.30 (s, 2H), 7.15 (s, 2H); MS 461 (M-HH+), 483 (M+Na+).
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Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/39359; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia