With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, molecular formula is C7H9Cl2N3S, molecular weight is 238.14, as common compound, the synthetic route is as follows.Computed Properties of C7H9Cl2N3S
Compound (1-a?) (524 mg, 2.2 mmol), compound (2?) (703 mmg, 2.4 mmol) and NaHCO3 (203 mg, 2.4 mmol) were added to DMF (25 ml). Under the nitrogen atmosphere, the mixture was stirred for 12-15 h at 90-95 C. The reaction was monitored by TLC. After completion, H2O (110 ml) and CH2Cl2 (110 ml) were added to the mixture and then stirring for 30 min. Then the aqueous and organic layers were separated. The CH2Cl2 was washed to neutral with H2O (25 ml*3). The organic layer was dried with anhydrous sodium sulfate, and then filtered. The CH2Cl2 layer was removed by distillation at reduced pressure to obtain crude product (compound (1-c?). The crude product was crystallized from a mixture of dichloromethane and petroleum ether to obtain a white solid (933 mg, yield 79.0%). HPLC purification is above 98%. 1HNMR (400 MHz, CDCl3) delta: 7.31-7.34 (m, 5H), 6.79 (b, 2H), 5.36 (s, 2H), 4.60-4.72 (m, 2H), 4.51-4.53 (m, 1H), 3.94 (d, J=7.6 Hz, 1H), 3.64-3.80 (m, 3H), 3.63-3.64 (m, 1H), 3.02-3.22 (m, 2H), 2.31-2.33 (m, 1H), 1.93-1.94 (m, 1H), 1.72-1.82 (m, 2H), 1.08 (t, J=7.6 Hz, 3H). MS (m/z): [M+H]+=495.15.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, and friends who are interested can also refer to it.
Reference:
Patent; BRIGHTGENE BIO-MEDICAL TECHNOLOGY (SUZHOU) CO., LTD; YUAN, Jiandong; JIANG, Qiao; LI, Xiang; US2015/322071; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia