Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-21-1, name is 4,6-Dichloropyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 4,6-Dichloropyrimidine
The 4,6-dichloropyrimidine 3.88g (26mmol) were dissolved in 40ml of isopropyl alcohol and p-anisidine 2.46g (20mmol), under stirring, 1.5ml of concentrated sulfuric acid was added dropwise, the reaction was heated at reflux for 6 hour monitoring of the reaction system. After completion of the reaction was cooled to room temperature, placed in 4 refrigerator overnight, the precipitated white solid was filtered off with suction, the filter cake was dried in an oven, to give 6-chloro -N- (4- methoxyphenyl) pyrimidin-4-amine The crude product 4.3g, 93% yield.
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Reference:
Patent; XI’AN JIAOTONG UNIVERSITY; ZHANG, JIE; ZHANG, TAO; DONG, JINYUN; PAN, XIAOYAN; HE, LANGCHONG; LU, WEN; WANG, SICEN; SHI, YALING; (19 pag.)CN104262263; (2017); B;,
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