Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2802-62-2, name is 4,6-Difluoropyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 4,6-Difluoropyrimidine
To a mixture of 1-[(1S,1R)-1-(4-fluoro-phenyl)-ethyl]-piperazine, Example 2(b), (0.50 g, 2.4 mmol) and 4,6-difluoropyrimidine (0.28 mL, 2.4 mmol, ABCR) in DMF (8 mL) was added cesium carbonate (2.3 g, 7.2 mmol) with stirring at 0 C. The reaction mixture was stirred at 0 C. for 20 min, diluted with H2O (20 mL) and extracted with DCM (2×40 mL). The combined organic extracts were washed with H2O (2×40 mL), dried over Na2SO4 and filtered. The filtrate was evaporated and the residue was dried in vacuo to yield the title compound. MS (ESI, pos. ion.) m/z: 305 (M+1)
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Reference:
Patent; Wang, Hui-Ling; Balan, Chenera; Doherty, Elizabeth M.; Falsey, James R.; Gore, Vijay Keshav; Katon, Jodie; Norman, Mark H.; US2005/176726; (2005); A1;,
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