Electric Literature of 5177-27-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5177-27-5, name is 5-Amino-2,4-dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
5-Amino-2,4-dichloropyrimidine (1.33 g, 10 mmol) and 5-aminoindazole (1.64 g, 10 mmol) were slurried in a solution of sodium acetate (20 mL, 0.1 M buffered to pH 4 with acetic acid). The reaction mixture was then heated to 60-65 C for 16 hours at which point no starting materials remained by t.l.c. The reaction mixture was cooled and the precipitate filtered off washed with water (20 mL), saturated sodium bicarbonate solution (10 mL) and again with water (2×20 mL). The solid was dried under vacuum for 12 hours (2.00 g, 7.6 mmol, 76% Yield). 1H,400MHz, delta (d6-DMSO): 5.68 (3H, br s, NH), 7.52 (2H, s, ArH), 7.61 (IH, s, ArH), 8.05 (IH, s, ArH), 8.06 (IH, s, ArH), 9.09 (IH, s, NH); HPLC: 3.95 min; LRMS: m/z = 261.1 (M+H)
According to the analysis of related databases, 5177-27-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DCAM PHARMA INC; AJAMI, Alfred, M.; DUNCAN, Kenneth, W.; FANG, Xinqin; WO2011/106168; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
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