With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine, molecular formula is C11H9ClN2O, molecular weight is 220.66, as common compound, the synthetic route is as follows.HPLC of Formula: C11H9ClN2O
To a 50 mL single-mouth bottle was added 5-benzyloxy-2-chloro-pyrimidine 34b (0.21 g, 0.95 mmol), morpholine (1.0 mL, 11 mmol), water (1 mL) and potassium carbonate (0.27 g, 1.9 mmol) The resulting reaction solution was stirred at 100 C for 19 hours.After the reaction solution was cooled to room temperature, the reaction solution was adjusted to pH = 3 with hydrochloric acid (1 mol/L).The mixture was extracted with EtOAc (EtOAc) (EtOAc)The title compound 46a (0.25 g, yield 96%) obtained as white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,138274-14-3, 5-(Benzyloxy)-2-chloropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Gu Zheng; Li Jianhao; Li Zheng; Wang Weihua; Tan Haoxiong; Wang Xuli; Cui Yunzeng; Xie Zeqiang; Zhang Yingjun; (101 pag.)CN109251166; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia