New learning discoveries about 5-Bromo-2-chloro-4-methoxypyrimidine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 57054-92-9, 5-Bromo-2-chloro-4-methoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 57054-92-9, Adding some certain compound to certain chemical reactions, such as: 57054-92-9, name is 5-Bromo-2-chloro-4-methoxypyrimidine,molecular formula is C5H4BrClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57054-92-9.

Step Z1 : (5-Bromo-4-methoxy-pyrimidin-2-yl)-methyl-amine A mixture of 5-bromo-2-chloro-4-methoxypyrimidine (3 g, 13.4 mmol) and methylamine (2 M in THF, 50 mL, 100 mmol) in THF (20 mL) was stirred for 40 h at rt and concentrated. The residue was purified by flash chromatography (hexane/EtOAc, 1 :1 ) to afford 2.5 g of the title compound. tR: 0.81 min (LC-MS 2) ; ESI-MS: 218/220.1 [M+H]+ (LC-MS 2); Rf: 0.39 (hexane/EtOAc 1 :1 ).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 57054-92-9, 5-Bromo-2-chloro-4-methoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; FURET, Pascal; GUAGNANO, Vito; HOLZER, Philipp; KALLEN, Joerg; LIAO, Lv; MAH, Robert; MAO, Liang; MASUYA, Keiichi; SCHLAPBACH, Achim; STUTZ, Stefan; VAUPEL, Andrea; WO2013/111105; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia