Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 50593-92-5, name is 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., Product Details of 50593-92-5
Acetyl chloride (6.26ml, 0.088mol) was added dropwise at 0-50C to methanol (100ml). The mixture was stirred at 0-50C for 5min. 5-Bromo-2- methylsulfanylpyrimidine-4-carboxylic acid (2Og, O.Odeltamol) was added in portions at 0-50C then the mixture was heated under reflux for Ih, during which time the slurry dissolved, then it was cooled to ambient temperature and poured into saturated aqueous sodium hydrogencarbonate solution (100ml). The product was extracted into dichloromethane (3xl00ml), the extracts were washed with water(100ml), dried (MgSO4) and evaporated in vacuo. The residual solid was crystallised from hexane to give 5-bromo-2-methylsulfanylpyrimidine-4-carboxylic acid methyl ester (12.27g) as an off white crystalline solid, m.pt. 67-700C; 250 MHz 1H-NMR (CDCl3) delta (ppm): 2.6 (s, 3H) (-SCH3), 4.05 (s, 3H) (-OCH3), 8.7 (s, IH) (ArH); m/z (M+H)+’ 249; HPLC purity 96%; HPLC retention time 1.58min.
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/88014; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia