Related Products of 1159981-95-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1159981-95-9, name is 5-Bromopyrazolo[1,5-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 5-bromopyrazolo[1,5-a]pyrimidine (200 mg, 1.00 mmol), Pd(PPh3)4 (117 mg, 0.101 mmol), copper(I) iodide (96 mg, 0.101 mmol), and hexa-n-butylditin (0.51 mL, 1.0 mmol) in toluene (0.5 mL) at 110 C. was added ethyl (S)-2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-(tert-butoxy)acetate (0.50 g, 1.0 mmol) in toluene (3 mL) over 30 minutes. Reaction mixture was stirred nine hours at 110 C., cooled to room temperature. Ethyl acetate and lithium chloride were added and stirred over the weekend. Reaction mixture was filtered, concentrated and purified by CombiFlash (ethyl acetate/hexanes) to give desired product. LCMS-ESI+: calc’d for C28H28ClN4O3S: 535.2 (M+H+); Found 535.2 (M+H+).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1159981-95-9, 5-Bromopyrazolo[1,5-a]pyrimidine.
Reference:
Patent; Gilead Sciences, Inc.; Cai, Zhenhong R.; Guo, Hongyan; Ji, Mingzhe; Jin, Haolun; Lee, Amy; McFadden, Ryan; Mitchell, Michael L.; Munoz, Manuel; Pyun, Hyung-Jung; Xu, Lianhong; Yang, Hong; (272 pag.)US2018/118734; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia