As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38275-61-5, name is 5-Chloropyrimidine-2-carboxylic acid, molecular formula is C5H3ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C5H3ClN2O2
Toa solution of 5-chloropyrimidine-2-carboxylic acid (0.16 g, 1.0 mmol) and (3S,3aS) -3- (aminomethyl) -7- (3-oxomorpholino) -3a, 4-dihydrobenzo [b] oxazolo[3, 4-d] [1, 4] oxazin-1 (3H) -one (0.32 g, 1.0 mmol) in N, N-dimethylformamide(10 mL) were added 1- (3-dimethylaminopropyl) -3-ethylcarbodiimidehydrochloride (0.38 g, 2.0 mmol) and 4-dimethylaminopyridine (0.31 g, 2.5 mmol). The mixture was reacted at rt for 10 hours. The reaction mixture wasconcentrated in vacuo to remove the solvent, and to the residue was addeddichloromethane (30 mL) . The resulting mixture was washed with aqueous sodiumhydroxide (10 mL, 2.0 mol/L) and water (10 mL) in turn, dried over anhydroussodium sulfate and filtered. The filtrate was concentrated in vacuo to remove thesolvent, and the crude product was purified by silica gel chromatography elutedwith DCM/MeOH (V/V) 30/1 to give the title compound as a white solid (0.167g, 36) . The compound was characterized by the following spectroscopic data:MS (ESI, pos. ion) m/z: 460.20 (M+1) and 1H NMR (400 MHz, d6-DMSO): delta 9.28 (t, J 6.0 Hz, 1H) , 9.10 (s, 2H) , 7.85 (d, J 8.7 Hz, 1H) , 7.05(d, J 2.2 Hz, 1H) , 7.01 (dd, J 8.7, 2.3 Hz, 1H) , 4.65 (dd, J 12.3, 5.6Hz, 1H) , 4.54 (dd, J 10.3, 3.0 Hz, 1H) , 4.17 (s, 2H) , 4.15 -4.01 (m, 2H) ,3.98 -3.92 (m, 2H) , 3.84 -3.74 (m, 2H) , 3.72 -3.65 (m, 2H) .
With the rapid development of chemical substances, we look forward to future research findings about 38275-61-5.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZUO, Yinglin; ZHANG, Yingjun; WANG, Xiaojun; ZHANG, Jin; WEN, Liang; CHENG, Guanjun; WO2015/110024; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia