Electric Literature of 5604-46-6 ,Some common heterocyclic compound, 5604-46-6, molecular formula is C5H3Cl2N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
N-(3-(4-aminomethylphenyl)phenyl)urea (10.0 g, 41.4 mmol)In ethanol (100mL) solution,Triethylamine (21.2g, 0.21mol) was addedAnd 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (8.0 g, 41.4 mmol).The reaction solution was heated to reflux with an oil bath and was reacted for about 6-7 hrs, and was monitored by TLC (dichloromethane:methanol = 10:1) until the reaction was completed.The solvent was evaporated under reduced pressure, water (200 mL) was evaporated, and then filtered and filtered, and the filter cake was recrystallized from ethanol and dried in vacuo to give 14.4 g of pale yellow solid as 2-amino-4-(4-(3-ureidobenzene) Base) benzylamino)-6-chloropyrimidine-5-carboxaldehyde in a yield of 88.4%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chengdu University of Technology; Zhou Lihong; (40 pag.)CN105111151; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia