As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 57489-77-7, name is 5,7-Dichloropyrazolo[1,5-a]pyrimidine, molecular formula is C6H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 5,7-Dichloropyrazolo[1,5-a]pyrimidine
To a solution of 5, 7-dichloro-pyrazolo[l,5-a]pyrimidine (1.0 mmol) and 2- 0’sopropylsulfonyl)aniline(1.0 mmol) in 5 mL of DMF, was added carefully NaH (24 mg). The resulting suspension was stirred at 500C for 2 hours. After cooling at RT and careful quenching (ice), water was added and the mixture was extracted with EtOAc. The organic layers were collected, dried (Na2SO4), filtrated and concentrated. The residue was purified over SiO2 column chromatography (eluent: 9: 1 Hexane: EtOAc), to give the desired 5-chloro-N-(2- (isopropylsulfonyl)phenyl)pyrazolo[l,5-a]pyrimidin-7-amine. MS (ES+): 351.06 (M+l)+.
With the rapid development of chemical substances, we look forward to future research findings about 57489-77-7.
Reference:
Patent; IRM LLC; WO2009/126514; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia