The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methylfuran-2(3H)-one( cas:591-12-8 ) is researched.Synthetic Route of C5H6O2.Thatikonda, Thanusha; Deepake, Siddharth K.; Das, Utpal published the article 《α-Angelica Lactone in a New Role: Facile Access to N-Aryl Tetrahydroisoquinolinones and Isoindolinones via Organocatalytic α-CH2 Oxygenation》 about this compound( cas:591-12-8 ) in Organic Letters. Keywords: tetrahydroisoquinolinone preparation; isoindolinone preparation; tetrahydroisoquinoline oxygenation organocatalyst; isoindoline oxygenation organocatalyst. Let’s learn more about this compound (cas:591-12-8).
A method for the direct oxidation of various N-aryl tetrahydroisoquinolines and isoindolines to the corresponding lactams using α-angelica lactone as a catalyst was developed. The utility of the method was further demonstrated by synthesis of indoprofen and indobufen.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia