The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Inverse-Electron-Demand Palladium-Catalyzed Asymmetric [4+2] Cycloadditions Enabled by Chiral P,S-Ligand and Hydrogen Bonding, the main research direction is enantioselective diastereoselective inverse electron demand palladium catalyzed cycloaddition; chiral phosphorus sulfur ligand palladium catalyzed asym cycloaddition; hydrogen bonding palladium catalyzed asym cycloaddition; P,S ligand; cycloaddition; heterocycles; hydrogen bonding; palladium.Related Products of 591-12-8.
Catalytic asym. cycloadditions of ambident Pd-containing dipolar species with nucleophilic dipolarophiles, namely, inverse-electron-demand cycloadditions, are challenging and underdeveloped. Possibly, the inherent linear selectivity of Pd-catalyzed intermol. allylations and the lack of efficient chiral ligands are responsible for this limitation. Herein, two cycloadditions of such intermediates with deconjugated butenolides and azlactones were accomplished by using a novel chiral hybrid P,S-ligand and hydrogen bonding [e.g., vinyl carbamate I + butenolide II → dihydroquinol-2-one III (92%, 93% ee, >95:5 d.r.)]. By doing so, highly functionalized, optically active dihydroquinol-2-ones were produced with generally high reaction efficiencies and selectivities. Preliminary DFT calculations were performed to explain the high enantio- and diastereoselectivities.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia