Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 6-Aminopyrimidine-2,4(1H,3H)-dione
6-Aminouracil (5) (5.18 g, 40.7 mmol) was suspended in HM DS (25 mL) and H2S04 (0.1 m L) was added. The mixture was heated at reflux for 3 h then concentrated in vacuo. The residue was dissolved in DM F (30 mL), Mel (8.5 mL, 136.5 mmol) was added, and stirring was continued for 72 h at room temperature. The reaction was cooled to 0 C and NaHC03 was carefully added. The mixture was stirred at 0 C until no more bubbling was observed. The precipitate was filtered, washed with MeOH and H20 and dried to give the title compound 6 (4.49 g, 78%) as a yellow solid which was used without further purification.Rf 0.23 (EtOAc-MeOH-N H4OH, 7:2.7:0.3);H NMR (400 MHz, DMSO-d6) delta 10.36 (1H, s, Ntf), 6.16 (2H, s, Ntf2), 4.56 (1H, s, tf-5); 3.04 (3H, s, NCtf3); 13C NMR (100 M Hz, DMSO-d6) delta 163.3 (C-4), 153.5 (C-6), 151.1 (C-2), 74.0 (C-5), 25.9 (NCH3);MP Lit: 327 C19, found: 320-323 C;
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Reference:
Patent; COMVITA LIMITED; BRIMBLE, Margaret Anne; SCHLOTHAUER, Ralf Christian; PRIJIC, Gordana; STEPHENS, Jonathan; DANIELS, Benjamin; (57 pag.)WO2017/99612; (2017); A1;,
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