Adding a certain compound to certain chemical reactions, such as: 56844-40-7, 6-Bromothieno[2,3-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 56844-40-7, blongs to pyrimidines compound. Safety of 6-Bromothieno[2,3-d]pyrimidin-4(3H)-one
Compound 5 (1.00 g, 4.33 mmol) was mixed with (2-methoxyphenyl)boronic acid (795 mg, 5.23 mmol), fine powdered K2CO3 (1.44 g, 10.39 mmol), Pd(PPh3)4 (50 mg, 0.04 mmol) and 1/1 1,4-dioxane/water (30 mL). The reaction was then stirred at 110 C for 5 h under nitrogen atmosphere. The solvent was removed and the product was diluted with water (50 mL). The mixture was filtered and the solid material washed with water (2¡Á75 mL). This was used without further purification. Drying gave 1.02 g (3.95 mmol, 91%) of 6 as a light brown solid, mp 317 C (dec.); 1H NMR (400 MHz, DMSO-d6) delta: 12.48 (s br, 1H), 8.12 (s, 1H), 7.85-7.81 (m, 2H), 7.41-7.35 (m, 1H), 7.21-7.16 (m, 1H), 7.08-7.03 (m, 1H), 3.95 (s, 3H); 13C NMR (100 MHz, DMSO-d6) delta: 163.8, 157.2, 155.3, 146.3, 135.3, 129.8, 128.0, 124.6, 121.2, 120.3, 118.6, 112.4, 55.8; IR (neat, cm-1): 3070, 1668, 1456, 1265, 1020, 865, 775, 759; HRMS (APCI/ASAP, m/z): 259.0537 (calcd. C13H11N2O2S, 259.0541, [M+H]+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56844-40-7, its application will become more common.
Reference:
Article; Bugge, Steffen; Moen, Ingri Ullestad; Kragseth Sylte, Kent-Ove; Sundby, Eirik; Hoff, Bard Helge; European Journal of Medicinal Chemistry; vol. 94; (2015); p. 175 – 194;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia