With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.866648-53-5, name is 6-Chloro-N,N-dimethyl-2-(trifluoromethyl)pyrimidin-4-amine, molecular formula is C7H7ClF3N3, molecular weight is 225.6, as common compound, the synthetic route is as follows.name: 6-Chloro-N,N-dimethyl-2-(trifluoromethyl)pyrimidin-4-amine
General procedure: 4-hydroxy was prepared in Reference Example 60 3- (piperidin-4-yl) -4- (trifluoromethyl) -1,4,5,7- tetrahydro -6H- pyrazolo [3,4-b] pyridin-6-one hydrochloride (100 mg, 0.293 mmol) in dimethyl sulfoxide (0.5 mL) solution of, N, N- diisopropylethylamine (59.8muL, 0.352mmol) and 3-chloro-6- (trifluoro methyl) pyridazine (80.2mg, 0.439mmol) was added, and the mixture was stirred overnight at room temperature.The reaction mixture was diluted with ethyl acetate, washed successively with water, saturated aqueous solution of ammonium chloride and brine, dried over anhydrous sodium sulfate, under reduced pressure, and the solvent was evaporated.The obtained residue was purified by silica gel column chromatography to obtain [eluent: ethyl acetate / methanol = 100 / 0-90 / 10 (gradient) to give the title compound (30% 39.8 mg, yield) It was.Instead of 3-chloro-6- (trifluoromethyl) pyridazine, using 6-chloro -N, N-dimethyl-2- (trifluoromethyl) pyrimidin-4-amine (150mg, 0.665mmol), carried the reaction was carried out in the same manner 80 C. manner to that described in example 43, the title compound (91 mg, yield: 28%) was obtained
At the same time, in my other blogs, there are other synthetic methods of this type of compound,866648-53-5, 6-Chloro-N,N-dimethyl-2-(trifluoromethyl)pyrimidin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; Daiichi Sankyo company limited; Sato, Rie; Kobayashi, Katsuhiro; Kaneko, Toshio; (188 pag.)JP2015/113323; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
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