Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 672-41-3, name is 6-(Trifluoromethyl)pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. 672-41-3
A solution of 6-(trifluoromethyl)pyrimidin-4-amine (0.143 g, 0.877 mmol) and 2-bromo-1-[2- ethylsulfonyl-4-[3-(trifluoromethyl)pyrazol-1-yl]phenyl]ethanone (0.34 g, 0.80 mmol) in acetonitrile (7 ml) in a Supeico microwave vial, was stirred for 1 hr at 150C. LC-MS showed the desired product and starting material. The reaction was thus stirred 1 hour more at 150C after which LCMS showed more product, less starting material. After a further 1 hour at 150C the reaction mixture was diluted with ethyl acetate, dried over Na2 S04, filtered and concentrated in vacuo. The crude product was purified by Combi flash chromatography with a column of 12 g and a gradient cyclohexane 0-60% ethyl acetate, to give the title compound as a beige solid. LCMS (method 1 ); Rt= 1.05 min, [M+H] 425/427. H NMR (400 MHz, CHLOROFORM-c/) delta ppm 1.26 (t, J=7.34 Hz, 3 H); 3.37 (q, J=7.34 Hz, 2 H); 6.84 (d, J=2.57 Hz, 1 H); 7.96 (d, J=8.44 Hz, 1 H); 7.98 (s, 1 H); 8.16 (d, J=1 .83 Hz, 1 H) 8.24 (dd, J=8.44, 2.20 Hz, 1 H) 8.33 (s, 1 H) 8.52 (d, J=2.57 Hz, 1 H) 9.19 (s, 1 H)
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Reference:
Patent; SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; JEANGUENAT, Andre; JUNG, Pierre Joseph Marcel; MUEHLEBACH, Michel; (150 pag.)WO2016/71214; (2016); A1;,
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