Adding a certain compound to certain chemical reactions, such as: 69785-94-0, 5-Aminopyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 69785-94-0, blongs to pyrimidines compound. COA of Formula: C4H5N3O
Example 62 5-Fluoro-N-(4-hydroxy-5-pyrimidinyl)-2-(3-methylsulfanyl-phenoxy)-nicotinamide 5-fluoro-2-(3-methylsulfanyl-phenoxy)-nicotinic acid (150 mg, 0.54 mmol) was dissolved in dimethylformamide (5 ml) and triethylamine (225 l, 1.61 mmol) was added followed by 3-amino-2-hydroxy-pyrimidine (85 mg, 0.56 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (113 mg, 0.59 mmol) and 1-hydroxybenzotriazole (80 mg, 0.59 mmol). The reaction was stirred under nitrogen at room temperature for 48 h and the solvent was removed under reduced pressure. The residue was partitioned between water (10 ml) and dichloromethane (20 ml) and the aqueous phase was extracted with dichloromethane (2*20 ml). The combined organic extracts were washed with brine (10 ml), dried over MgSO4 and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel using dichloromethane:methanol:ammonia (95:5:0.5) as eluent to give the title compound (80 mg) as an off-white solid. 1H NMR (400 MHz, D6-DMSO): delta=12.85 (1H, brs), 10.43 (1H, brs), 8.90 (1H, s), 8.34 (1H, d), 8.27-8.30 (1H, dd), 8.04 (1H, s), 7.35-7.39 (1H, t), 7.21 (1H, s), 7.14-7.16 (1H, d), 7.04-7.07 (1H, d) ppm. N.B. Suspect peak hidden under DMSO peak 3.52 (3H, s) ppm. LRMS (electrospray): m/z [M+Na]+ 395 and [M-H]- 371. Anal. Found C, 54.76; H, 3.53; N, 14.81. C17H13FN4O3S requires C, 54.83; H, 3.52; N, 15.05%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69785-94-0, its application will become more common.
Reference:
Patent; Pfizer Inc; US2005/20587; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia