In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine, the common compound, a new synthetic route is introduced below. Computed Properties of C7H9ClN4O2
4-amino-3-fluoro-N-(4-methylpiperazin-1-yl)benzamide(5.0g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4 hours, cooled to room temperature, filtered, washed and dried to obtain a yellow solid(6.5g) in a yield of 75.7%. 1H NMR(400 MHz, DMSO-d6): delta 10.11(s, 1H), 9.47(s, 1H), 8.99(s, 1H), 8.38(d, J=7.6Hz, 1H), 7.86(m, 1H), 7.65(m, 2H), 4.27(m, 1H), 2.89(t, J=4.8Hz, 4H), 2.42(br, 4H), 2.19(s, 3H), 1.23(d, J=6.4Hz, 6H)ppm.
The synthetic route of 890094-38-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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