In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99844-02-7, name is 4-(4-Methoxyphenyl)pyrimidin-2-amine, the common compound, a new synthetic route is introduced below. name: 4-(4-Methoxyphenyl)pyrimidin-2-amine
Sodium t-butoxide is added to a stirred suspension of anilino-pyrimidines, substituted sulfones, tris(dibenzylideneacetone)dipalladium(0), and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl in dioxane. The mixture is heated at 80 C. for 72 hours. The reaction is cooled to room temperature, and the mixture is filtered and washed with THF and MeOH. The solvent is removed by evaporation, and the residue is purified by pre-plate with EtOAc/MeOH (10:1.5).
The synthetic route of 99844-02-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wyeth; US2006/79543; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia