With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine, molecular formula is C16H11ClN2, molecular weight is 266.73, as common compound, the synthetic route is as follows.Formula: C16H11ClN2
Under an atmosphere of argon, a 300 mL three-necked flask was charged with intermediate (a) (5.6 g, 21 mmol) 2-Bromocarbazole (5.43 g, 22.1 mmol), Potassium carbonate (3.48 g, 25.2 mmol), Dimethylformamide (DMF, 50 mL) was added and the mixture was refluxed at 100 for 8 hours. After the reaction solution was cooled to room temperature, insolubles were removed by filtration, and the organic solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain intermediate (h) (9.0 g, yield 90%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Idemitsu Kosan Corporation; Nishimura, Kazuki; Ito, Mitsunori; Inoue, Tetsuya; (48 pag.)KR2015/92145; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia