New learning discoveries about Quality Control of 6-Chloro-5-iodopyrimidin-4-amine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 6-Chloro-5-iodopyrimidin-4-amine, blongs to pyrimidines compound. Quality Control of 6-Chloro-5-iodopyrimidin-4-amine

Compound (S)-3-(1-Aminoethyl)-2-cyclopropyl-8-fluoroisoquinolin-1(2H)-one (425 mg, 1.726 mmol),6-chloro-5-iodopyrimidine-4-amine (463.8 mg, 1.816 mmol) andA mixture of DIPEA (445.5 mg, 3.447 mmol) in n-butanol (2.5 mL) was heated to 130 C and stirring was continued for 30 hours.After cooling to room temperature and concentrating under reduced pressure, EtOAc m.The crude product was purified by silica gel column chromatography (EtOAc/EtOAc)The title compound was obtained as a pale yellow solid (250 mg, 31%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wang Tingjin; Wu Weibin; (84 pag.)CN105130966; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia