Niedzwicki, John G.;Iltzsch, Max H.;El Kouni, Mahmoud H.;Cha, Sungman published 《Structure-activity relationship of pyrimidine base analogs as ligands of orotate phosphoribosyltransferase》 in 1984. The article was appeared in 《Biochemical Pharmacology》. They have made some progress in their research.Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione The article mentions the following:
Eighty pyrimidine base analogs were evaluated as inhibitors of mouse liver orotate phosphoribosyltransferase (I) (EC 2.4.2.10). Based on these findings and an extensive literature review, a structure-activity relation was formulated for the binding of pyrimidine base analogs to I. A basis for the rational design of new inhibitors of I is provided, and several such compounds are proposed. Addnl., 4,6-dihydroxypyrimidine was found to be a potent I inhibitor. Eleven I inhibitors were also evaluated as inhibitors of orotidine 5′-monophosphate decarboxylase (II) (EC 4.1.2.23). 5-Azauracil, 5-azaorotate, and barbituric acid inhibited II significantly after preincubation with PRPP and MgCl2 in the presence of cytosol.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.
6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia