O’Brien, Darrell E.; Springer, Robert H.; Cheng, C. C. published the artcile< New Mannich reaction of pyrimidines>, Safety of 5-Hydroxypyrimidin-4(3H)-one, the main research area is .
4,5-Dihydroxypyrimidines undergo the Mannich reaction with primary and secondary amines and CH2O at the 6-position. 5-Hydroxy-6-piperidinomethyluracil, 3,6-dimethyl-3,4-dihydro-2H-pyrimido[4,5-e]-1,3-oxazin-8-ol (I, R = Me), and the 6-OH analog of I were prepared in this manner. The new Mannich reaction appears to be a general method for the synthesis of compounds containing the new 3,4-dihydro-2H-pyrimido[4,5-e]-1,3-oxazine ring system.
Journal of Heterocyclic Chemistry published new progress about Mannich reaction. 15837-41-9 belongs to class pyrimidines, and the molecular formula is C4H4N2O2, Safety of 5-Hydroxypyrimidin-4(3H)-one.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia