Formula: C6H3Cl2N3In 2014 ,《Synthesis and biological evaluation of substituted 2-anilino-7H-pyrrolopyrimidines as PDK1 inhibitors》 appeared in Tetrahedron. The author of the article were O’Brien, Nathan J.; Brzozowski, Martin; Wilson, David J. D.; Deady, Leslie W.; Abbott, Belinda M.. The article conveys some information:
An efficient and scalable route for a series of novel substituted 2-aniline-7H-pyrrolopyrimidine compounds as potential inhibitors of PDK1, an important regulator of the PI3K/Akt pathway that is dysregulated in many cancers, was developed and is described. The synthetic strategy was designed around a Suzuki coupling and Buchwald-Hartwig cross-coupling of a boronate fragment and various customized aniline derivatives sequentially with 2,4-dichloro-7-tosyl-7H-pyrrolopyrimidine. All fragments were constructed sep. and cross-coupled to provide access to a range of novel compounds Biol. evaluation of these was undertaken, with modest inhibition observed The synthesis of the target compounds was achieved using N-[3-amino-5-[2-oxo-2-[[2-(1-piperidinyl)ethyl]amino]ethyl]phenyl]-1-pyrrolidinecarboxamide, 3-amino-N-[2-(1-piperidinyl)ethyl]benzeneacetamide, 3-amino-N-[2-(1-piperidinyl)ethyl]benzamide and 2,4-dichloro-7-[(4-methylphenyl)sulfonyl]-7H-Pyrrolo[2,3-d]pyrimidine as key intermediates.2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Formula: C6H3Cl2N3) was used in this study.
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Formula: C6H3Cl2N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia