Ok, Tae-Dong published the artcileGNA/aegPNA Chimera Loaded with RNA Binding Preference, Recommanded Product: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid, the publication is Chemistry – An Asian Journal (2011), 6(8), 1996-1999, database is CAplus and MEDLINE.
The authors have found a very simple strategy to improve binding preference of aegPNA [aeg = N-(2-aminoethyl)glycine] to RNA/DNA. Inspired by the structure of the GNA (glycol nucleic acid) monomer, a highly simple chiral PNA monomer was designed. By incorporating a few chiral acyclic γ-amino acid mols. into the achiral aegPNA backbone, the authors were able to make a chimeric PNA (chiPNA) with better RNA selectivity as well as antiparallel selectivity. The authors feel, to the best of their knowledge, this is the simplest monomeric unit that induces aegPNA to discriminate between RNA and DNA. Finally, the authors demonstrate that the chip-based competition-binding assay is an alternative tool to the quant. anal. of binding selectivities of modified PNAs. The authors believe that chiPNAs will expand the utility of PNAs and find diverse applications related to RNA targets in the future.
Chemistry – An Asian Journal published new progress about 169396-92-3. 169396-92-3 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Amide,Others,PNA, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C26H26N4O7, Recommanded Product: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia