Oka, Yoshimi; Shishino, Hisae published the artcile< Fluorescence Imaging of Disrupted Interfaces between Liquid-Ordered and Liquid-Disordered Domains by a Flavin-Labeled PNA Duplex>, Computed Properties of 2244-11-3, the main research area is fluorescence imaging interface liquid ordered disordered domain flavin PNA.
Lipid rafts and membrane-active peptides are attracting attention because they help understand basic membrane functions. In addition, the authors focus on flavoproteins playing some physiol. roles and explore the model compounds A new flavin probe, composed of palmitoylated peptide nucleic acid (PNA) and its complementary PNA labeled with flavin, targets the liquid-ordered (lo) microdomains and disrupts its interfaces to liquid-disordered (ld) microdomains of giant unilamellar vesicles and can be visualized by using confocal laser scanning microscopy. Surprisingly, as shown in time-lapse images, vesiculation and probe aggregations appear in the lo-ld interfaces, which leads to local disruption of the membrane. A possible interpretation of the data based on comparison with control experiments are discussed.
ACS Omega published new progress about Biological imaging. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Computed Properties of 2244-11-3.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia