Okafor, Charles O.; Steenberg, Marie L.; Buckley, Joseph P. published an article in 1977, the title of the article was Studies in the heterocyclic series. XIII. New CNS-depressants derived from 1,9-diazaphenoxazine and two isomeric triazaphenothiazine ring systems.Application In Synthesis of 5-Bromo-2,4,6-trichloropyrimidine And the article contains the following content:
Triazaphenothiazines I (R = NH2, H, SMe, OMe; R1 = NH2, Me, Cl, OH, OMe) and II (R = H, NH2, Cl; R1 = NH2, OH, Cl; R2 = MeO, Cl) were prepared in 78-93% yield. Reaction of 2-amino-3-mercapto-6-picoline with 2-amino-5-bromo-4-chloro-6-methylpyrimidine in the presence of H2SO4 and Na2SO3 gave 77% I (R = NH2, R1 = Me). All I and II showed appreciable CNS depressant activities comparable with the activity of chlorpromazine when tested in mice and rats; I (R = H, R1 = NH2) and II (R = R1 = Cl, R2 = MeO) were the most promising. All I and II decreased motor activity and rate of respiration within 30 min and body temperature was decreased by 0.5-1.9° compared to 0.8° with chlorpromazine. The experimental process involved the reaction of 5-Bromo-2,4,6-trichloropyrimidine(cas: 63931-21-5).Application In Synthesis of 5-Bromo-2,4,6-trichloropyrimidine
The Article related to depressant triazaphenothiazine, triazaphenothiazine, phenothiazine triaza, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines (Including Cephalosporins) and other aspects.Application In Synthesis of 5-Bromo-2,4,6-trichloropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia