Oppenlaender, Thomas; Pfoertner, Karl Heinz; Schoenholzer, Peter published an article in Helvetica Chimica Acta. The title of the article was 《Photooxygenation of 5-aryl-2,4-diaminopyrimidines leading to 4-amino-1,3,5-triazin-2-yl ketones and, in the presence of sodium borohydride, to 5,6-dihydro-4(3H)-pyrimidinones》.Related Products of 15400-54-1 The author mentioned the following in the article:
The photosensitized oxygenation of 5-aryl-2,4-diaminopyrimidines I (R = 4-ClC6H4, Ph; R1 = Et, H Me, Ph) in protic solvents led to the formation of the new 4-amino-1,3,5-triazin-2-yl ketones II in high yields. The structures of II were elucidated by spectroscopic means, especially by 13C-NMR and UV data. Photooxygenation of I (R = 4-ClC6H4, R1 = Et) under reductive conditions, e.g. in the presence of excess of NaBH4, gave 5,6-dihydro-5-hydroxy-4(3H)-pyrimidinone III, the structure of which was determined by x-ray anal. In the proposed mechanisms for both types of reactions, a dipolar ion formed by attack of 1O2 on C5 is assumed to be a common intermediate. For the new efficient synthesis of 1,3,5-triazines from 2,4-diaminopyrimidines, a 5-aryl substituent seems to be essential. In the experiment, the researchers used many compounds, for example, Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1Related Products of 15400-54-1)
Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Related Products of 15400-54-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia