On September 12, 2012, Ouyang, Wuqing; Zhou, Ying; Ouyang, Shenyu published a patent.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Veterinary drug of compound tulathromycin nanoemulsion and preparation method thereof. And the patent contained the following:
The title compound tulathromycin nanoemulsion with particle size of 1-100 nm is prepared from surfactant 30-40, co-surfactant 5-15, oily phase 5-15, tulathromycin 2-5, trimethoprim lactate 0.5-1.25%, and deionized water as balance by conventional method. The surfactant is one or more of EL-40, RH-40, Tween-80, and poloxamer 188. The co-surfactant is one or more of ethanol, 1,2-propanediol, glycerol, and PEG-600. The oily phase is one or more of Et acetate, Bu acetate, iso-Pr myristate, Et oleate, etc. The inventive compound tulathromycin nanoemulsion can obtain good bactericidal/bacteriostatic effect by injection once, has rapid onset of drug action and sustained-release effect, and can avoid first pass effect in liver and reduce the stress response of animals. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
The Article related to tulathromycin nanoemulsion trimethoprim lactate microfiltration veterinary antimicrobial, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia