Safety of 3-(Pyrimidin-5-yl)benzaldehydeOn October 15, 2013 ,《The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Patel, Bhargav A.; Ashby, Charles R.; Hardej, Diane; Talele, Tanaji T.. The article contains the following contents:
A focused library of rhodanine compounds containing novel substituents at the C5-position was synthesized and tested in vitro against a panel of clin. relevant MRSA strains. The present SAR study was based on our lead compound I (Ar = 3-phenoxyphenyl) (MIC = 1.95 μg/mL), with a focus on identifying optimal C5-arylidene substituents. In order to obtain this objective, we condensed several unique aromatic aldehydes with phenylalanine-derived rhodanine intermediates to obtain C5-substituted target rhodanine compounds for evaluation as anti-MRSA compounds These efforts produced three compounds with significant efficacy: I [Ar = 3-(3,4-dichloro)phenoxyphenyl, 3-biphenyl] and II with MIC values ranging from 0.98 to 1.95 μg/mL against all tested MRSA strains as compared to the reference antibiotics penicillin G (MIC = 15.60-250.0 μg/mL) and ciprofloxacin (MIC = 7.80-62.50 μg/mL) and comparable to that of vancomycin (MIC = 0.48 μg/mL). In addition, several other compounds (MIC = 1.95-3.90 μg/mL) were efficacious against all MRSA strains. The majority of the synthesized compounds had bactericidal activity at concentrations only two to fourfold higher than their MIC. Overall, the results suggest that compounds I [Ar = 3-(3,4-dichloro)phenoxyphenyl, 3-biphenyl] and II may be of potential use in the treatment of MRSA infections. The experimental part of the paper was very detailed, including the reaction process of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Safety of 3-(Pyrimidin-5-yl)benzaldehyde)
3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Safety of 3-(Pyrimidin-5-yl)benzaldehydeThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia