The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Reference of 109-12-6.
Patel, Sagarkumar;Globisch, Christoph;Pulugu, Priyanka;Kumar, Prasoon;Jain, Alok;Shard, Amit research published 《 Novel imidazopyrimidines-based molecules induce tetramerization of tumor pyruvate kinase M2 and exhibit potent antiproliferative profile》, the research content is summarized as follows. Here, the unprecedented development of imidazopyrimidines I [R = Ph, 2-CNC6H4, 3-ClC6H4C(O), etc.; X = N] and imidazopyridines I [X = CH2] based tumor pyruvate kinase M2 (PKM2) modulators by subsequent link and grow strategy was disclosed. The most potent modulator compound I [R = 3,4-di-ClC6H3; X = N] acts as a PKM2 activator with an AC50 of 90 nM, with considerable cancer cell-selectivity and membrane-permeability. NMR metabolomics studied also revealed that treatment with compound I [R = 3,4-di-ClC6H3; X = N] results in diminution in lactate concentrations in MCF-7 cells. Compound I [R = 3,4-di-ClC6H3; X = N] binded to a previously reported site at PKM2 adjacent to the interface of two monomers. In mol. dynamics (MD) simulation studies, it was observed that compound I [R = 3,4-di-ClC6H3; X = N] stabilized the PKM2 at the dimeric interface, assisting in the formation of a biol. active tetramer conformation. Compound I [R = 3,4-di-ClC6H3; X = N] was also screened on MCF-7 breast cancer cell lines grown on 3-D scaffolds and the results exhibited better anticancer potential compared to control, paving the way for future clin. studies.
109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Reference of 109-12-6
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia