Identification of potent and selective MTH1 inhibitors was written by Petrocchi, Alessia;Leo, Elisabetta;Reyna, Naphtali J.;Hamilton, Matthew M.;Shi, Xi;Parker, Connor A.;Mseeh, Faika;Bardenhagen, Jennifer P.;Leonard, Paul;Cross, Jason B.;Huang, Sha;Jiang, Yongying;Cardozo, Mario;Draetta, Giulio;Marszalek, Joseph R.;Toniatti, Carlo;Jones, Philip;Lewis, Richard T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.COA of Formula: C5H6ClN3 This article mentions the following:
Structure based design of a novel class of aminopyrimidine MTH1 (MutT homolog 1) inhibitors is described. Optimization led to identification of I, a sub-nanomolar inhibitor of MTH1 with excellent cell permeability and good metabolic stability in microsomes. This compound robustly inhibited MTH1 activity in cells and proved to be an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncol. In the experiment, the researchers used many compounds, for example, 4-Chloro-5-methylpyrimidin-2-amine (cas: 20090-58-8COA of Formula: C5H6ClN3).
4-Chloro-5-methylpyrimidin-2-amine (cas: 20090-58-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.COA of Formula: C5H6ClN3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia