Picazo, Edwige M. H.; Heptinstall, Amy B.; Wilson, David M.; Cano, Celine; Golding, Bernard T.; Waring, Michael J. published the artcile< Cyclizations and fragmentations in the alkylation of 6-chloro-5-hydroxy-4-aminopyrimidines with aminoalkyl chlorides>, Electric Literature of 5018-38-2, the main research area is polysubstituted aminopyrimidine preparation; chlorohydroxyaminopyrimidine aminoalkyl chloride alkylation.
Substituted aminopyrimidines are an important class of compounds, in part because they frequently show biol. activity. Facile synthesis of polysubstituted aminopyrimidines is highly desirable for the synthesis of screening libraries. Authors describe a route to 4,6-diamino-5-alkoxypyrimidines via a SNAr-alkylation-SNAr sequence from readily available 4,6-dichloro-5-methoxypyrimidine, which allows the synthesis of such compounds with regiochem. control. The extension of this approach to alkylating agents bearing amino substituents led to unexpected and, in some cases, unprecedented products resulting from intramol. SNAr cyclization and subsequent fragmentation.
Journal of Heterocyclic Chemistry published new progress about Alkylation. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, Electric Literature of 5018-38-2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia