Piechowicz, Katarzyna A. et al. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016 | CAS: 39083-15-3

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C7H10N2OS

Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1 was written by Piechowicz, Katarzyna A.;Truong, Eric C.;Javed, Kashif M.;Chaney, Rachelle R.;Wu, Johnny Y.;Phuan, Puay W.;Verkman, Alan S.;Anderson, Marc O.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016.COA of Formula: C7H10N2OS The following contents are mentioned in the article:

Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca2+ activated Cl– channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and elec. excitable cells. TMEM16A inhibitors have potential utility for treatment of disorders of epithelial fluid and mucus secretion, hypertension, some cancers and other diseases. 4-Aryl-2-amino thiazole was previously identified by high-throughput screening. Here, a library of 47 compounds were prepared that explored the 5,6-disubstituted pyrimidine scaffold found in. TMEM16A inhibition activity was measured using fluorescence plate reader and short-circuit current assays. The authors found that very little structural variation of was tolerated, with most compounds showing no activity at 10 渭M. The most potent compound in the series, which substitutes 4-methoxyphenyl in with 2-thiophene, had IC50 éˆ? 渭M for inhibition of TMEM16A chloride conductance. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3COA of Formula: C7H10N2OS).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C7H10N2OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia