The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine.
Price, Daniel J.;Drewry, David H.;Schaller, Lee T.;Thompson, Brian D.;Reid, Paul R.;Maloney, Patrick R.;Liang, Xi;Banker, Periette;Buckholz, Richard G.;Selley, Paula K.;McDonald, Octerloney B.;Smith, Jeffery L.;Shearer, Todd W.;Cox, Richard F.;Williams, Shawn P.;Reid, Robert A.;Tacconi, Stefano;Faggioni, Federico;Piubelli, Chiara;Sartori, Ilaria;Tessari, Michela;Wang, Tony Y. research published 《 An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model》, the research content is summarized as follows. Hypothalamic CAMKK2 represents a potential mechanism for chem. affecting satiety and promoting weight loss in clin. obese patients. Single-digit nanomolar inhibitors of CAMKK2 were identified in three related ATP-competitive series. Limited optimization of kinase selectivity, solubility, and pharmacokinetic properties were undertaken on all three series, as SAR was often transferrable. Ultimately, a 2,4-diaryl 7-azaindole was optimized to afford a tool mol. that potently inhibits AMPK phosphorylation in a hypothalamus-derived cell line, is orally bioavailable, and crosses the blood-brain barrier. When dosed orally in rodents, compound 4t limited ghrelin-induced food intake.
2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia