Synthesis of pyrido[2,3-d]pyrimidinones by the reaction of aminopyrimidin-4-ones with benzylidene Meldrum’s acid derivatives was written by Quiroga, Jairo;Hormaza, Angelina;Insuasty, Braulio;Nogueras, Manuel;Sanchez, Adolfo;Hanold, Norbert;Meier, Herbert. And the article was included in Journal of Heterocyclic Chemistry in 1997.Quality Control of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:
A series of pyrido[2,3-d]pyrimidine-4,7-diones I (R1 = MeS, MeO; R2 = H, Me; R3 = H, Cl, NO2) were prepared from 6-amino-4-pyrimidinones (II) and benzylidene Meldrum’s acid derivatives (III) by cyclization reactions in boiling nitrobenzene. The structure of I, determined by NMR measurements, reveals a selective orientation of II and III in the addition step. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Quality Control of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Quality Control of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia