Synthesis of new 6-aroylpyrido[2,3-d]pyrimidines was written by Quiroga, Jairo;Viveros, German;Insuasty, Braulio;Nogueras, Manuel;Sanchez, Adolfo;Cobo, Justo. And the article was included in Journal of Heterocyclic Chemistry in 1999.Computed Properties of C6H9N3OS This article mentions the following:
The synthesis of 6-dimethylaminomethylenaminopyrimidin-4(3H)-ones (2) and its reaction with β-dimethylaminopropiophenone hydrochloride (3) is discussed. The reaction of 6-aminopyrimidin-4(3H)-ones with an excess of DMF di-Me acetal gives 6-dimethylaminomethyleneaminopyrimidines 2. Heating of equimol. quantities of 2 and 3 in DMF leads to 6-aroylpyrido[2,3-d]pyrimidine derivatives In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Computed Properties of C6H9N3OS).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Computed Properties of C6H9N3OS
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia